業績

AuthorTitleYearJournal/ProceedingsLink
齋藤駿&井本正哉
天然物ケミカルバイオロジー研究の現状–前立腺がん治療薬を例として– 2017年 月刊ケミカルエンジニアリング 2017年10月号 (VOL.62 No.10) pp52-58   Google Scholar
PubMed
Y. Hanaki, Y. Shikata, M. Kikumori, N. Hotta, M. Imoto, K. Irie
Identification of Protein Kinase C Isozymes Involved in the Anti-Proliferative and Pro-Apoptotic Activities of 10-Methyl-aplog-1, a Simplified Analog of Debromoaplysiatoxin, in Several Cancer Cell Lines 2017年 in press Biochem. Biophys. Res. Commun.   Google Scholar
PubMed
Y. Shikata, M. Kiga, Y. Futamura, H. Aono, H. Inoue, M. Kawada, H. Osada, M. Imoto
Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. 2017年 Cancer Science   Google Scholar
PubMed
Y. Shikata, M. Kiga, Y. Futamura, H. Aono, H. Inoue, M. Kawada, H. Osada, M. Imoto
Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. 2017年 Cancer Science   Google Scholar
PubMed
S. Saito, T. Fujimaki, W. Panbangred, R. Sawa, Y. Igarashi, M. Imoto
Antarlides F-H, new members of the antarlide family produced by Streptomyces sp. BB47. 2017年 J. Antiobiot. Google Scholar
PubMed
T. Fujimaki, S. Saitoh, M. Imoto
Arabilin overcomes resistance to AR-targeted therapy 2017年 J. Antiobiot.   Google Scholar
PubMed
E. Tashiro, S. Henmi, H. Odake, S. Ino, M. Imoto
Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation 2016年 Biochem. Biophys. Res. Commun.   Google Scholar
PubMed
H.Ikeda, Y. Shikata, R. Watanapokasin, E. Tashiro, M. Imoto
Metacycloprodigiosin induced cell death selectively in β-catenin-mutated tumor cells 2016年 J. Antiobiot.   Google Scholar
PubMed
S.Ioka, T. Saitoh, S. Iwano, K. Suzuki, S. Maki, A. Miyawaki, M. Imoto, S. Nishiyama
Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties 2016年 Chemistry - A European Journal 22, 1-9   Google Scholar
PubMed
S.Saito, T. Fujimaki, P. Watanalai, Y. Igarashi, M. Imoto
Antarlides, New-type Androgen Receptor (AR) Antagonists, That Overcome Resistance to AR-targeted Therapy 2016年 Angewandte Chemie International Edition   Google Scholar
PubMed
K. Haruna, M. Koda, S. Saitoh, M. Imoto, M. Kawada, Y. Yamazaki, I. Momose, K. Shindo,
Biological activities of unique isoflavones prepared from Apios americana Medik 2016年 Bioscience, Biotechnology, and Biochemistry,  Google Scholar
PubMed
E.Tashiro, M. Imoto
Chemistry and biology of the compounds that modulate cell migration (Review Article) 2015年 Journal of Industrial Microbiology & Biotechnology   Google Scholar
PubMed
E.Tashiro, M. Imoto
Chemical biology of compounds obtained from screening using disease models (Review Article) 2015年 Archives of Pharmacal Research, 38(9):1651-60   Google Scholar
PubMed
Y. Mizotani, S. Itoh, K. Hotta, E. Tashiro, K. Oka, M. Imoto
Evaluation of drug toxicity profiles based on the phenotypes of ascidian Ciona intestinalis 2015年 Biochem. Biophys. Res. Commun. 463(4):656-60   Google Scholar
PubMed
井本正哉
ビッグデータを利用した標的同定の実例 「生物活性分子のケミカルバイオロジー-標的同定と作用機構」15

2015年

 

化学同人 79-85   Google Scholar
PubMed
井本正哉 & 川谷誠
分子標的同定の実例 「生物活性分子のケミカルバイオロジー-標的同定と作用機構」 2015年 カレントレビュー19 化学同人 26-33   Google Scholar
PubMed
A. Krajarng , M. Imoto, E. Tashiro, T. Fujimaki , S. Shinjo, R. Watanapokasin
Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid. 2015年 BMC Complementary and Alternative Medicine, 15:26   Google Scholar
PubMed
M. Kiga, A. Nakayama, Y. Shikata, Y. Sasazawa, R. Murakami, T. Nakanishi, E. Tashiro, M. Imoto
SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in b-catenin-mutated tumors. 2015年 Scientific Report, 5: 8155   Google Scholar
PubMed
T. Yoshimaru, M. Komatsu, E. Tashiro, M. Imoto, H. Osada, M. Miyoshi, J. Honda, M. Sasa, T. Katagiri
Xanthohumol suppresses oestrogen-signalling in breast cancer through the specific inhibition of BIG3-PHB2 interaction. 2014年 Scientific Report, 4: 7335   Google Scholar
PubMed
T. Fujimaki, S. Saiki, E. Tashiro, D. Yamada, M. Kitagawa, N. Hattori, M. Imoto
Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson’s disease. 2014年 PLoS One, 9 (6): e100395   Google Scholar
PubMed
S. Magi , Y. Saeki, M. Kasamatsu, E. Tashiro, M. Imoto
Chemical genomic-based pathway analyses for epidermal growth factor-mediated signaling in migrating cancer cells 2014年 PLoS One, 9 (5): e96776   Google Scholar
PubMed
北川光洋, 田代悦 & 井本正哉
オートファージに挑むケミカルバイオロジー 2014年 化学工業, 65(4), pp22-27   Google Scholar
PubMed
田代悦 & 井本正哉
最新がん薬物療法学
-がん薬物療法の最新知見-
EMTを標的としたがん治療
2014年 日本臨牀, 72巻, 増刊号2, 90-96  Google Scholar
PubMed
K. Sakata, M. Hara, T. Terada, N. Watanabe, D. Takaya, S. Yaguchi, T. Matsumoto, T. Matsuura, M. Shirouzu, S. Yokoyama, T. Yamaguchi, K. Miyazawa, H. Aizaki, T. Suzuki, T. Wakita, M. Imoto & S. Kojima
Neovessel formation promotes liver fibrosis via providing latent transforming growth factor-β 2013 Biochemical and Biophysical Research Communications  Google Scholar
PubMed
K. Sakata, S. Eda, E. Lee, M. Hara, M. Imoto, S. Kojima
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor 2013 Scientific Reports 3, Article number: 3243  Google Scholar
PubMed
S. Magi, Y. Takemoto, H. Kobayashi, M. Kasamatsu, T. Akita, A. Tanaka, K. Takano, E. Tashiro, Y. Igarashi, M. Imoto
5‐Lipoxygenase and CysLT1 regulate EGF‐induced cell migration through Tiam1 upregulation and Rac1 activation 2013 Cancer science  Google Scholar
PubMed
M. Ichige, E. Fukuda, S. Miida, J. Hattan, N. Misawa, S. Saito, T. Fujimaki, M. Imoto, and K. Shindo
Novel Isoflavone Glucosides in Groundnut (Apios americana Medik) and Their Antiandrogenic Activities 2013 Journal of Agricultural and Food Chemistry, 61 (9), pp 2183–2187  Google Scholar
PubMed
S. Shinjo, E. Tashiro and M. Imoto
Establishment of a New Detection System for the Dimerization of IRE1α by BiFC Assay 2013 Bioscience, Biotechnology, and Biochemistry, 77(6), 1333-1336  Google Scholar
PubMed
S. Shinjo, Y. Mizotani, E. Tashiro and M. Imoto
Comparative Analysis of the Expression Patterns of UPR Target Genes caused by UPR-inducing Compounds 2013 Bioscience, Biotechnology, and Biochemistry, 77(4), 729-735  Google Scholar
PubMed
T. J. Zimmermann, M. Burger, E. Tashiro, Y. Kondoh, N. E. Martinez, K. Gçrmer, S. Rosin-Steiner, T. Shimizu, S. Ozaki, K. Mikoshiba, N. Watanabe, D.Hall, I. R. Vetter, H. Osada, C. Hedberg, and H.Waldmann
Boron-Based Inhibitors of Acyl Protein Thioesterases 1 and 2 2013 ChemBioChem Vol. 14, p115-122  Google Scholar
PubMed
田代悦 & 井本正哉
キナーゼ阻害剤の分類・作用機序 2013 Bio Clinica (2013) Vol. 28 (1), p18-22  Google
S. Magi, T. Shitara, Y. Takemoto, M. Sawada, M. Kitagawa, E. Tashiro, Y. Takahashi & M. Imoto
Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase in press The Journal of Antibiotics  Google Scholar
PubMed
藤巻貴宏 & 井本正哉
ケミカルバイオロジーと構造生物学—制がん剤のシードの探索- 分子標的薬(がんから他疾患までの治癒を目指して) 2012 日本臨床
70巻 増刊号8, pp. 303-307 
Google
S. Magi, E. Tashiro & M. Imoto
A chemical genomic study identifying diversity in cell migration signaling in cancer cells 2012 Scientific Reports
Vol. 2 
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PubMed
K. Yamamoto, M. Makino, R. Watanapokasin, E. Tashiro and M. Imoto
Inostamycin enhanced TRAIL-induced apoptosis through DR5 up regulation on the cell surface 2012 The Journal of Antibiotics  Google Scholar
PubMed
Kimura.T, Kanagaki S, Matsui Y, Imoto M, Watanabe T, Shibasaki M.
Synthesis and Assignment of the Absolute Configuration of an Indenotryptoline Bisindole Alkaloid, BE-54017 2012 Org. Lett.
Vol.14, pp. 4418-4421 (2012) 
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PubMed
北川光洋 & 井本正哉
がんの代謝解析による薬剤標的探索 2012 実験医学
増刊, pp. 173-177 
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Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S.
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing 2012 Blood Cancer J.
e79  
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PubMed
Kobayashi H, Harada, H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura S, Shin-ya K, Doi T, Takahashi T, Natsume T, Imoto M and Sakakibara Y.
Comprehensive Predictions of Target Proteins Based on Protein-Chemical Interaction Using Virtual Screening and Experimental Verifications 2012 BMC Chemical Biology
12: 2 
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PubMed
M. Kiga, F. Tanzawa, S. Iwasaki, F. Inaba, K. Fujiwara, H. Iwadare, T. Echigo, Y. Nakamura, T. Shibata, K. Suzuki, I. Yasumatsu, A. Nakayama, Y. Sasazawa, E. Tashiro, M. Imoto & S. Kurakata
Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17. 2012 Anti-cancer drugs
Vol. 23(1), pp. 119-130 
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PubMed
Y. Sasazawa, S. Kanagaki, E. Tashiro, T. Nogawa, M. Muroi, Y. Kondoh, H. Osada & M. Imoto
Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. 2012 ACS Chemical Biology
Vol. 18, pp. 892-900 
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PubMed
E. Tashiro & M. Imoto
Target identification of bioactive compounds. 2012 Bioorganic & medicinal chemistry
Vol. 20(6), pp. 1910-1921 
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PubMed
K. Yamamoto, E. Tashiro, K. Motohashi, H. Seto & M. Imoto
Napyradiomycin A1, an inhibitor of mitochondrial complexes I and II. 2012 The Journal of Antibiotics
Vol. 65, pp. 211-214 
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PubMed
木我真基 & 井本正哉
分子標的治療薬の創薬過程 2011 細胞
Vol. 43(4), pp. 127-130 
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T. Kawamura, K. Matsubara, H. Otaka, E. Tashiro, K. Shindo, R. C. Yanagita, K. Irie & M. Imoto
Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP. 2011 Bioorganic & medicinal chemistry
Vol. 19(14), pp. 4377-4385 
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PubMed
M. Kitagawa, M. Misawa, S. Ogawa, E. Tashiro & M. Imoto
A new, convenient cell-based screening method for small-molecule glycolytic inhibitors. 2011 Bioscience, Biotechnology, and Biochemistry
Vol. 75(2), pp. 367-369 
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PubMed
H. Kobayashi, Y. Ogura, M. Sawada, R. Nakayama, K. Takano, Y. Minato, Y. Takemoto, E. Tashiro, H. Watanabe & M. Imoto
Involvement of 14-3-3 proteins in the second epidermal growth factor-induced wave of Rac1 activation in the process of cell migration. 2011 The Journal of Biological Chemistry
Vol. 286(45), pp. 39259-39268 
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PubMed
S. Saiki, Y. Sasazawa, Y. Imamichi, S. Kawajiri, T. Fujimaki, I. Tanida, H. Kobayashi, F. Sato, S. Sato, K.-I. Ishikawa, M. Imoto & N. Hattori
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. 2011 Autophagy
Vol. 7(2), pp. 176-187 
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PubMed
M. Sawada, S.-i. Kubo, K. Matsumura, Y. Takemoto, H. Kobayashi, E. Tashiro, T. Kitahara, H. Watanabe & M. Imoto
Synthesis and anti-migrative evaluation of moverastin derivatives. 2011 Bioorganic & medicinal chemistry letters
Vol. 21(5), pp. 1385-1389 
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PubMed
K. Tsumura, A. Suzuki, T. Tsuzuki, S. Tanimoto, H. Kaneko, S. Matsumura, M. Imoto, K. Umezawa, D. Takahashi & K. Toshima
Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α. 2011 Organic & Biomolecular Chemistry
Vol. 9(18), pp. 6357-6366 
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PubMed
Y. Yamada, E. Tashiro, S. Taketani, M. Imoto & T. Kataoka
Cheminform abstract: mycotrienin ii (i), a translation inhibitor that prevents ICAM-1 expression induced by proinflammatory cytokines. 2011 ChemInform
Vol. 42(36), pp. no-no 
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PubMed
Y. Yamada, E. Tashiro, S. Taketani, M. Imoto & T. Kataoka
Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines. 2011 The Journal of Antibiotics
Vol. 64(5), pp. 361-366 
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PubMed
K. Yamamoto, E. Tashiro & M. Imoto
Quinotrierixin inhibited ER stress-induced XBP1 mRNA splicing through inhibition of protein synthesis. 2011 Bioscience, Biotechnology, and Biochemistry
Vol. 75(2), pp. 284-288 
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PubMed
笹澤有紀子 & 井本正哉
アポトーシス耐性のがんに挑む-V-ATPase阻害剤の新たな可能性- 2010 生体の科学
Vol. 61, pp. 614-618 
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PubMed
G. Hamanaka, M. Matsumoto, M. Imoto & H. Kaneko
Mesenchyme cells can function to induce epithelial cell proliferation in starfish embryos. 2010 Developmental Dynamics : an Official Publication of the American Association of Anatomists
Vol. 239(3), pp. 818-827 
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PubMed
T. Kawamura, T. Fujimaki, N. Hamanaka, K. Torii, H. Kobayashi, Y. Takahashi, M. Igarashi, N. Kinoshita, Y. Nishimura, E. Tashiro & M. Imoto
Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1. 2010 The Journal of Antibiotics
Vol. 63(10), pp. 601-605 
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M. Kitagawa, S. Ikeda, E. Tashiro, T. Soga & M. Imoto
Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A. 2010 Chemistry & Biology
Vol. 17(9), pp. 989-998 
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PubMed
T. Ohtani, S. Tsukamoto, H. Kanda, K. Misawa, Y. Urakawa, T. Fujimaki, M. Imoto, Y. Takahashi, D. Takahashi & K. Toshima
Total synthesis of incednam, the aglycon of incednine. 2010 Organic Letters
Vol. 12(21), pp. 5068-5071 
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PubMed
M. Shirai, M. Okuda, K. Motohashi, M. Imoto, K. Furihata, Y. Matsuo, A. Katsuta, Y. Shizuri & H. Seto
Terpenoids produced by actinomycetes: isolation, structural elucidation and biosynthesis of new diterpenes, gifhornenolones A and B from Verrucosispora gifhornensis YM28-088. 2010 The Journal of Antibiotics
Vol. 63(5), pp. 245-250 
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PubMed
M. Takeuchi, S. Kimura, J. Kuroda, E. Ashihara, M. Kawatani, H. Osada, K. Umezawa, E. Yasui, M. Imoto, T. Tsuruo, A. Yokota, R. Tanaka, R. Nagao, T. Nakahata, Y. Fujiyama & T. Maekawa
Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment. 2010 Cell death and differentiation
Vol. 17(7), pp. 1211-1220 
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PubMed
M. Urscher, J. M. Przyborski, M. Imoto & M. Deponte
Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of Plasmodium falciparum glyoxalases. 2010 Molecular Microbiology
Vol. 76(1), pp. 92-103 
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PubMed
笹澤有紀子 & 井本正哉
抗がん剤の効かないがんに挑むーアポトーシス抑制タンパク質Bcl-xL機能阻害剤の発見ー 2009 化学
Vol. 64(11), pp. 74-75 
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PubMed
小林大貴 & 井本正哉
細胞遊走を標的とするケミカルジェネティクス 2009 細胞工学
Vol. 28, pp. 345-351 
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PubMed
田代悦 & 井本正哉
微生物生理活性物質のケミカルバイオロジー 2009 化学と生物
Vol. 47, pp. 193-201 
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河村達郎, 田代悦 & 井本正哉
ケミカルバイオロジーに基づく創薬研究、分子標的薬開発の新たなる挑戦 2009 実験医学
Vol. 増刊, pp. 213-220 
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M. Kanai, E. Tashiro, H. Maruki, Y. Minato & M. Imoto
Transcriptional regulation of human fibroblast growth factor receptor 1 by E2F-1. 2009 Gene
Vol. 438(1-2), pp. 49-56 
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M. Kanai, S. Iba, R. Okada, E. Tashiro & M. Imoto
Oligomycin induced the proteasomal degradation of cyclin D1 protein. 2009 The Journal of Antibiotics
Vol. 62(8), pp. 425-429 
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N. Nagamine, T. Shirakawa, Y. Minato, K. Torii, H. Kobayashi, M. Imoto & Y. Sakakibara
Integrating statistical predictions and experimental verifications for enhancing protein-chemical interaction predictions in virtual screening. 2009 PLoS Computational Biology
Vol. 5(6), pp. e1000397 
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Y. Sasazawa, Y. Futamura, E. Tashiro & M. Imoto
Vacuolar H+-ATPase inhibitors overcome Bcl-xL-mediated chemoresistance through restoration of a caspase-independent apoptotic pathway. 2009 Cancer Science
Vol. 100(8), pp. 1460-1467 
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Y. Futamura, R. Sawa, Y. Umezawa, M. Igarashi, H. Nakamura, K. Hasegawa, M. Yamasaki, E. Tashiro, Y. Takahashi, Y. Akamatsu & M. Imoto
Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin. 2008 Journal of the American Chemical Society
Vol. 130(6), pp. 1822-1823 
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M. Imoto
[Bioprobe generation from microbial origin for chemical biology study]. 2008 Nihon Yakurigaku Zasshi. Folia Ppharmacologica Japonica
Vol. 132(1), pp. 26-30 
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PubMed
T. Kawamura, E. Tashiro, K. Yamamoto, K. Shindo & M. Imoto
SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation. I.Taxonomy, fermentation, Isolation, biological activities and SAR study 2008 The Journal of Antibiotics
Vol. 61(5), pp. 303-311 
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T. Kawamura, E. Tashiro, K. Shindo & M. Imoto
SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation. II. Structure elucidation. 2008 The Journal of Antibiotics
Vol. 61(5), pp. 312-317 
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M. Kawatani, H. Okumura, K. Honda, N. Kanoh, M. Muroi, N. Dohmae, M. Takami, M. Kitagawa, Y. Futamura, M. Imoto & H. Osada
The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I. 2008 Proceedings of the National Academy of Sciences of the United States of America
Vol. 105(33), pp. 11691-11696 
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H. J. Kwon, C. H. Lee, H. Osada, M. Yoshida & M. Imoto
Hot springs and cool natural products. 2008 Nature Chem Biology, pp. 444-446  Google Scholar
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Y. Minato, Y. Nihei, Y. Kodama, E. Tashiro, M. Kanai & M. Imoto
Identification and characterization of mouse type II platelet-derived growth factor receptor alpha transcript. 2008 Bioscience, Biotechnology, and Biochemistry
Vol. 72(3), pp. 759-766 
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K. Uno, T. Tanabe, T. Ogamino, R. Okada, M. Imoto & S. Nishiyama
ChemInform Abstract: Synthesis and Antitumor Activity of Combretastatin D-4. 2008 ChemInform
Vol. 39(25) 
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Y. Minato, E. Tashiro, M. Kanai & M. Imoto
K. Yoshida (Ed.)
Control of cellular physiology by E2F transcription factors (Chaptor 8. Involvement of E2F in cellular proliferation by regulating growth factor receptor expression) 2008   Google Scholar
PubMed
二村友史 & 井本正哉
ここまで来た分子標的治療 「分子標的治療のターゲット1 細胞増殖」 2007 臨床婦人科産科
Vol. 61, pp. 1224-1229 
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竹本靖 & 井本正哉
生理活性物質のケミカルバイオロジー「ファルネシルトランスフェラーゼ阻害剤の癌分指標的治療薬への展開」 2007 蛋白質 核酸 酵素
Vol. 52, pp. 1713-1718 
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北川光洋 & 井本正哉
分子標的薬開発への挑戦 「ケミカルバイオロジーと創薬研究」 2007 バイオテクノロジージャーナル
Vol. 7, pp. 501-504 
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二村友史 & 井本正哉
微生物の復権:小分子の宝庫「微生物代謝産物を用いたケミカルバイオロジー」 2007 バイオインダストリー
Vol. 7, pp. 30-38 
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Y. Futamura, E. Tashiro, N. Hironiwa, J. Kohno, M. Nishio, K. Shindo & M. Imoto
Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from streptomyces sp. II. structure elucidation. 2007 The Journal of Antibiotics
Vol. 60(9), pp. 582-585 
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Y. Minato, E. Tashiro, M. Kanai, Y. Nihei, Y. Kodama & M. Imoto
Transcriptional regulation of a new variant of human platelet-derived growth factor receptor alpha transcript by E2F-1. 2007 Gene
Vol. 403(1-2), pp. 89-97 
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Y. Takemoto & M. Imoto
Development of farnesyltransferase inhibitor for anti-cancer drugs. 2007 Tanpakushitsu kakusan koso. Protein, Nucleic Aacid, Enzyme
Vol. 52(13 Suppl), pp. 1713-1718 
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E. Tashiro, N. Hironiwa, M. Kitagawa, Y. Futamura, S.-I. Suzuki, M. Nishio & M. Imoto
Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from streptomyces sp. I. taxonomy, fermentation, isolation and biological activities. 2007 The Journal of Antibiotics
Vol. 60(9), pp. 547-553 
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E. Tashiro, A. Tsuchiya & M. Imoto
Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. 2007 Cancer Science
Vol. 98(5), pp. 629-635 
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A. Tsuchiya, E. Tashiro, M. Yoshida & M. Imoto
Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expression. 2007 Oncogene
Vol. 26(11), pp. 1522-1532 
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M. S. Islam, M. Kitagawa, M. Imoto, T. Kitahara & H. Watanabe
Synthesis of gerfelin and related analogous compounds. 2006 Bioscience, Biotechnology, and Biochemistry
Vol. 70(10), pp. 2523-2528 
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H. Osada, M. Hagiwara, K. Toshima & M. Imoto
The education system for chemical biology in Japanese universities. 2006 ACS Chemical Biology
Vol. 1(8), pp. 492-494 
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Y. Takemoto, E. Tashiro & M. Imoto
Suppression of multidrug resistance by migrastatin. 2006 The Journal of Antibiotics
Vol. 59(7), pp. 435-438 
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T. Tanabe, T. Ogamino, Y. Shimizu, M. Imoto & S. Nishiyama
Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity. 2006 Bioorganic & medicinal chemistry
Vol. 14(8), pp. 2753-2762 
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井本正哉
RasおよびRhoファミリータンパク質の翻訳後修飾阻害剤による癌悪性化の制御 2005 生化学
Vol. 77, pp. 511-518 
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M. Imoto
[Regulation of tumor malignancy by inhibitors of posttranslational modification of Ras and Rho family proteins]. 2005 Seikagaku. The Journal of Japanese Biochemical Society
Vol. 77(6), pp. 511-518 
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S. Kosuga, E. Tashiro, T. Kajioka, M. Ueki, Y. Shimizu & M. Imoto
GSK-3beta directly phosphorylates and activates MARK2/PAR-1. 2005 The Journal of Biological Chemistry
Vol. 280(52), pp. 42715-42722 
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J. Nakazawa, N. Watanabe, M. Imoto & H. Osada
Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae. 2005 The Journal of General and Applied Microbiology
Vol. 51(4), pp. 245-256 
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A. Shimbashi, A. Tsuchiya, M. Imoto & S. Nishiyama
Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity. 2005 Bioorganic & medicinal chemistry letters
Vol. 15(1), pp. 61-65 
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Y. Takemoto, H. Watanabe, K. Uchida, K. Matsumura, K. Nakae, E. Tashiro, K. Shindo, T. Kitahara & M. Imoto
Chemistry and biology of moverastins, inhibitors of cancer cell migration, produced by Aspergillus. 2005 Chemistry & Biology
Vol. 12(12), pp. 1337-1347 
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A. Tsuchiya, E. Tashiro, M. Yoshida & M. Imoto
Involvement of nuclear accumulation of heat shock protein 27 in leptomycin B-induced apoptosis in HeLa cells. 2005 The Journal of Antibiotics
Vol. 58(12), pp. 810-816 
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井本正哉
RasおよびRhoファミリータンパク質の翻訳後修飾阻害剤による癌悪性化の制御 2005 生化学
Vol. 77, pp. 511-518 
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井本正哉
マチニブ・メシレートの基礎と臨床 1.チロシンキナーゼとその阻害薬 2004 血液フロンティア
Vol. 4, pp. 13-22 
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A. Shimbashi, A. Tsuchiya, M. Imoto & S. Nishiyama
The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp. and Their Related Substances 2004 Bulletin of the Chemical Society of Japan
Vol. 77(10), pp. 1925-1930 
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井本正哉
イマチニブチ・メシレート(グリベック)への期待と可能性 2. チロシンキナーゼとその阻害薬 2003 医薬ジャーナル
Vol. 37, pp. 97-104 
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M. Kawatani & M. Imoto
Deletion of the BH1 domain of Bcl-2 accelerates apoptosis by acting in a dominant negative fashion. 2003 The Journal of Biological Chemistry
Vol. 278(22), pp. 19732-19742 
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M. Kawatani, M. Uchi, S. Simizu, H. Osada & M. Imoto
Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis. 2003 Experimental Cell Research
Vol. 286(1), pp. 57-66 
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J. Nakazawa, J. Yajima, T. Usui, M. Ueki, A. Takatsuki, M. Imoto, Y. Y. Toyoshima & H. Osada
A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5. 2003 Chemistry & Biology
Vol. 10(2), pp. 131-137 
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K. Sanpei, Y. Saito, M. Imoto, K. Umezawa & K. Kato
Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase 2003 Bioorganic & medicinal chemistry letters
Vol. 6(21), pp. 2487-2490 
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E. Tashiro, Y. Minato, H. Maruki, M. Asagiri & M. Imoto
Regulation of FGF receptor-2 expression by transcription factor E2F-1. 2003 Oncogene
Vol. 22(36), pp. 5630-5635 
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E. Tashiro, H. Maruki, Y. Minato, Y. Doki, I. B. Weinstein & M. Imoto
Overexpression of cyclin D1 contributes to malignancy by up-regulation of fibroblast growth factor receptor 1 via the pRB/E2F pathway. 2003 Cancer Research
Vol. 63(2), pp. 424-431 
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S. Zenitani, S. Tashiro, K. Shindo, K. Nagai, K. Suzuki & M. Imoto
Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. 2003 The Journal of Antibiotics
Vol. 56(7), pp. 617-621 
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S. Zenitani, K. Shindo, S. Tashiro, M. Sekiguchi, M. Nishimori, K. Suzuki & M. Imoto
Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. II. Structural elucidation. 2003 The Journal of Antibiotics
Vol. 56(7), pp. 658-660 
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H. Nakamura, Y. Takahashi, H. Naganawa, K. Nakae, M. Imoto, M. Shiro, K. Matsumura, H. Watanabe & T. Kitahara
Absolute configuration of migrastatin, a novel 14-membered ring macrolide. 2002 The Journal of Antibiotics
Vol. 55(4), pp. 442-444 
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M. Shintani, A. Okazaki, T. Masuda, M. Kawada, M. Ishizuka, Y. Doki, I. B. Weinstein & M. Imoto
Overexpression of cyclin D1 contributes to malignant properties of esophageal tumor cells by increasing VEGF production and decreasing Fas expression. 2002 Anticancer Research
Vol. 22(2A), pp. 639-647 
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Y. Yoshimoto & M. Imoto
Induction of EGF-dependent apoptosis by vacuolar-type H(+)-ATPase inhibitors in A431 cells overexpressing the EGF receptor. 2002 Experimental Cell Research
Vol. 279(1), pp. 118-127 
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Y. Yoshimoto, T. Jyojima, T. Arita, M. Ueda, M. Imoto, S. Matsumura & K. Toshima
Vacuolar-type H(+)-ATPase inhibitory activity of synthetic analogues of the concanamycins: is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? 2002 Bioorganic & medicinal chemistry letters
Vol. 12(24), pp. 3525-3528 
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井本正哉
バイオの窓「大学における物取り研究」 2001 バイオサイエンスとインダストリー
Vol. 59, pp. 43 
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井本正哉
微生物由来細胞内情報伝達系に作用する物質の探索研究 2001 Japanese Journal of Antibiotics
Vol. 54, pp. 117-125 
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Y. Baba, M. Tsukuda, I. Mochimatsu, S. Furukawa, H. Kagata, Y. Nagashima, S. Koshika, M. Imoto & Y. Kato
Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines. 2001 Cell biology international
Vol. 25(7), pp. 613-620 
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M. Imoto
[Study of the novel compounds modulating signal transduction system from microbial origin]. 2001 The Japanese journal of antibiotics, pp. 117-125  Google Scholar
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Y. Takemoto, K. Nakae, M. Kawatani, Y. Takahashi, H. Naganawa & M. Imoto
Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells. 2001 The Journal of Antibiotics
Vol. 54(12), pp. 1104-1107 
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Y. Baba, M. Tsukuda, I. Mochimatsu, S. Furukawa, H. Kagata, Yoji, Nagashima, N. Sakai, S. Koshika, M. Imoto & Y. Kato
Inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, suppresses invasion ability by reducing productions of matrix metalloproteinase-2 and -9 and cell motility in HSC-4 tongue carcinoma cell line. 2000 Clinical & experimental metastasis
Vol. 18(3), pp. 273-279 
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N. Endo, E. Tashiro, K. Umezawa, M. Kawada, Y. Uehara, Y. Doki, I. B. Weinstein & M. Imoto
Herbimycin A induces G1 arrest through accumulation of p27(Kip1) in cyclin D1-overexpressing fibroblasts. 2000 Biochem Biophys Res Commun
Vol. 267(1), pp. 54-58 
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M. Kawatani, S. Simizu, H. Osada, M. Takada, N. Arber & M. Imoto
Involvement of protein kinase C-regulated ceramide generation in inostamycin-induced apoptosis. 2000 Experimental Cell Research
Vol. 259(2), pp. 389-397 
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Y. Matsumoto, M. Kawatani, S. Simizu, T. Tanaka, M. Takada & M. Imoto
Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells. 2000 Anticancer Research
Vol. 20(5A), pp. 3123-3129 
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K. Nakae, Y. Yoshimoto, T. Sawa, Y. Homma, M. Hamada, T. Takeuchi & M. Imoto
Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. 2000 The Journal of Antibiotics
Vol. 53(10), pp. 1130-1136 
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K. Nakae, Y. Yoshimoto, M. Ueda, T. Sawa, Y. Takahashi, H. Naganawa, T. Takeuchi & M. Imoto
Migrastatin, a novel 14-membered lactone from Streptomyces sp. MK929-43F1. 2000 The Journal of Antibiotics
Vol. 53(10), pp. 1228-1230 
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M. Imoto
H. Osada (Ed.)
Bioprobes 2000   Google Scholar
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Y. Yao, Y. Doki, W. Jiang, M. Imoto, V. S. Venkatraj, D. Warburton, R. M. Santella, B. Lu, L. Yan, X. H. Sun, T. Su, J. Luo & I. B. Weinstein
Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins. 2000 Experimental Cell Research
Vol. 257(1), pp. 22-32 
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Y. Yoshimoto, T. Sawa, H. Naganawa, T. Sugai, T. Takeuchi & M. Imoto
MK800-62F1, a new inhibitor of apoptotic cell death, from Streptomyces diastatochromogenes MK800-62F1. II. Structure elucidation. 2000 The Journal of Antibiotics
Vol. 53(6), pp. 575-578 
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Y. Yoshimoto, T. Sawa, N. Kinoshita, Y. Homma, M. Hamada, T. Takeuchi & M. Imoto
MK800-62F1, a new inhibitor of apoptotic cell death, from Streptomyces diastatochromogenes MK800-62F1. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. 2000 The Journal of Antibiotics
Vol. 53(6), pp. 569-574 
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井本正哉
細部周期とアポトーシス 1999 アポトーシスと疾患 癌編, pp. 42-51  Google
井本正哉
細胞周期阻害剤を用いた細胞周期制御機構の解析 1999 Cytometry Research
Vol. 8, pp. 29-33 
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M. Imoto, K. Tanabe, S. Simizu, E. Tashiro, M. Takada & K. Umezawa
Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells. 1998 Japanese Journal of Cancer Research : Gann
Vol. 89(3), pp. 315-322 
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S. Simizu, K. Umezawa, M. Takada, N. Arber & M. Imoto
Induction of hydrogen peroxide production and Bax expression by caspase-3(-like) proteases in tyrosine kinase inhibitor-induced apoptosis in human small cell lung carcinoma cells. 1998 Experimental Cell Research
Vol. 238(1), pp. 197-203 
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S. Simizu, K. Tanabe, E. Tashiro, M. Takada, K. Umezawa & M. Imoto
Potentiation of paclitaxel cytotoxicity by inostamycin in human small cell lung carcinoma, Ms-1 cells. 1998 Japanese Journal of Cancer Research : Gann
Vol. 89(9), pp. 970-976 
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S. Simizu, M. Takada, K. Umezawa & M. Imoto
Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs. 1998 The Journal of Biological Chemistry
Vol. 273(41), pp. 26900-26907 
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E. Tashiro, S. Simizu, M. Takada, K. Umezawa & M. Imoto
Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells. 1998 Japanese Journal of Cancer Research : Gann
Vol. 89(9), pp. 940-946 
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T. Watanabe, M. Imoto, H. Taniguchi, K. Kinoshita & K. Umezawa
Synthesis of fluorescent substrates for protein tyrosine phosphatase assays. 1998 Bioorganic & medicinal chemistry letters
Vol. 8(11), pp. 1301-1302 
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Y. Doki, M. Imoto, E. K. Han, A. Sgambato & I. B. Weinstein
Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1. 1997 Carcinogenesis
Vol. 18(6), pp. 1139-1148 
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S. Fujiwara, T. Watanabe, T. Nagatsu, J. Gohda, M. Imoto & K. Umezawa
Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells. 1997 Biochem Biophys Res Commun
Vol. 238(1), pp. 213-217 
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M. Imoto, Y. Doki, W. Jiang, E. K. Han & I. B. Weinstein
Effects of cyclin D1 overexpression on G1 progression-related events. 1997 Experimental Cell Research
Vol. 236(1), pp. 173-180 
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H. Ui, T. Miyake, H. Iinuma, M. Imoto, H. Naganawa, S. Hattori, M. Hamada, T. Takeuchi, S. Umezawa & K. Umezawa
Pholipeptin, a novel cyclic lipoundecapeptide from Pseudomonas fluorescens 1997 Journal of Organic Chemistry
Vol. 62(1), pp. 103-108 
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K. Umezawa, A. Deguchi & M. Imoto
Screening of phosphatidylinositol turnover inhibitors and regulation of cell cycle progression. 1997 Gan to kagaku ryoho. Cancer & chemotherapy
Vol. 24(11), pp. 1578-1584 
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A. Deguchi, M. Imoto & K. Umezawa
Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor. 1996 Journal of biochemistry
Vol. 120(6), pp. 1118-1122 
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S. Simizu, M. Imoto, N. Masuda, M. Takada & K. Umezawa
Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. 1996 Cancer Research
Vol. 56(21), pp. 4978-4982 
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井本正哉
細胞情報伝達系に作用する物質の発見と細胞応答の解析 1995 日本農芸化学会誌
Vol. 69, pp. 1309-1315 
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M. Imoto, S. Tanaka, A. Deguchi, A. Hayakawa & K. Umezawa
In situ inhibition of protein-tyrosine phosphatase by dephostatin 1995 Cell Pharmacology
Vol. 2, pp. 199-203 
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H. Ui, T. Miyake, H. Iinuma, M. Imoto, S. Hattori, M. Hamada, T. Takeuchi, S. Umezawa & K. Umezawa
A novel cyclic lipoundecapeptide, pholipeptin, isolated from Pseudomonas sp. 1995 Tetrahedron Letters
Vol. 36(41), pp. 7479-7480 
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Y. Mizutani, S. Masuoka, M. Imoto, M. Kawada & K. Umezawa
Induction of erythroid differentiation in leukaemic K562 cells by an S-adenosylhomocysteine hydrolase inhibitor, aristeromycin 1995 Biochemical and Biophysical Research Communications
Vol. 207, pp. 69-74 
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M. I. M. K. Y Mizutani, S Masuoka & K. Umezawa
nduction of erythroid differentiation in leukaemic K562 cells by an S-adenosylhomocysteine hydrolase inhibitor, aristeromycin 1995 Biochem Biophys Res Commun
Vol. 207, pp. 69-74 
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H. Nishioka, M. Imoto, T. Imaoka, T. Sawa, T. Takeuchi & K. Umezawa
Antitumor effect of piericidin B1 N-oxide 1994 Experimental Cell Research, pp. 228-233  Google Scholar
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M. Imoto, T. Morii, A. Deguchi & K. Umezawa
Involvement of phosphatidylinositol synthesis in the regulation of S-phase induction 1994 Experimental Cell Research
Vol. 215(228-233) 
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M. Imoto, T. Nakamura, S. Tanaka & K. Umezawa
Inhibition of T cell receptor-mediated signal transduction by erbstatin 1994 Bioscience, Biotechnology, and Biochemistry  Google Scholar
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M. Imoto, Y. Taniguchi, H. Fujiwara & K. Umezawa
Enhancement of CDP-DG:inositol transferase activity in src- and erbB2-transformed cells 1994 Experimental Cell Research
Vol. 212, pp. 151-154 
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S. Simizu, M. Imoto & K. Umezawa
Induction of apopsotis by erbstatin in mouse in leukaemia L1210 cells 1994 Bioscience, Biotechnology, and Biochemistry
Vol. 58, pp. 1549-1552 
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H. Ui, M. Imoto & K. Umezawa
Inhibition of Phosphatidylinositol-specifie Phospholipase C Activity by Fluvirucin B2 1994 Journal of Antibiotics
Vol. 48(5) 
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梅沢一夫 & 井本正哉
イノシトールリン脂質代謝回転阻害剤の探索と生物活性 1993 実験医学
Vol. 11, pp. 124-2129 
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H. Kakeya, M. Imoto, Y. Tabata, J. Iwami, H. Matsumoto, K. Nakamura, T. Koyano, K. Tadano & K. Umezawa
Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis 1993 FEBS Letters
Vol. 320, pp. 169-172 
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H. Kakeya, M. Imoto, Y. Takahashi, H. Naganawa, T. Takeuchi & K. Umezawa
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination 1993 Journal of Antibiotics
Vol. 46, pp. 1716-11719 
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M. Imoto, K. Kakeya, T. Sawa, C. Hayashi, M. Hamada, T. Takeuchi & K. Umezawa
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, Isolation, and Characterization 1993 Journal of Antibiotics
Vol. 46, pp. 1342-1346 
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M. Imoto, I. Sujikai, H. Ui & K. Umezawa
Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells 1993 Biochimica et Biophysica Acta
Vol. 1166, pp. 188-192 
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T. Hiramatsu, M. Imoto, T. Koyano & K. Umezawa
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia 1993 Cancer Letters(73), pp. 161-166  Google Scholar
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井本正哉 & 梅沢一夫
ホスファチジルイノシトール代謝回転阻害剤と細胞周期の制御 1992 Cell Science
Vol. 8, pp. 595-601 
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M. Imoto, Y. Taniguchi & K. Umezawa
Inhibition of CDP-DG:inositol transferase by inostamycin 1992 Journal of biochemistry
Vol. 112, pp. 299-302 
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T. Hori, T. Kondo, T. Tsuji, M. Imoto & K. Umezawa
Inhibition of tyrosine kinase and src oncogene functions by stable erbstatin analogues. 1992 Journal of Antibiotics
Vol. 45, pp. 280-282 
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Y. Tabata, M. Imoto & K. Umezawa
Biosynthetic preparation of radioactively labeled erbstatin 1992 Journal of Antibiotics
Vol. 45, pp. 1382-1384 
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K. Umezawa & M. Imoto
Use of erbstatin as a protein-tyrosine kinase inhibitor 1991 Methods in Enzymology
Vol. 201, pp. 379-385 
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K. Umezawa, K. Tanaka, T. Hori, S. Abe, R. Sekizawa & M. Imoto
Induction of morphological change by tyrosine kinase inhibitors in Rous sarcoma virus-transformed rat kidney cells 1991 FEBS Letters
Vol. 279, pp. 132-136 
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M. Imoto, N. Johtoh & K. Umezawa
Inhibition by phosphatidylinositol turnover inhibitors of epidermal growth factor-induced rounding of A431 cells. 1991 Journal of Cell Pharmacology
Vol. 2, pp. 49-53 
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M. Imoto, N. Shimura & K. Umezawa
Inhibition of epidermal growth factor-induced activation of phospholipase C by psi-tectorigenin 1991 Journal of Antibiotics
Vol. 44, pp. 915-917 
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M. Kawada, M. Imoto & K. Umezawa
Suppression of multidrug resistance by inostamycin in cultured human carcinoma KB cells 1991 Journal of Cell Pharmacology
Vol. 2, pp. 138-142 
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H. Nishioka, T. Sawa, M. Hamada, N. Shimura, M. Imoto & K. Umezawa
Inhibition of phosphatidylinositol kinase by toyocamycin 1990 Journal of Antibiotics, pp. 1586-1589  Google Scholar
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K. Umezawa, T. Hori, H. Tajima, M. Imoto, K. Isshiki & T. Takeuchi
Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors 1990 FEBS Letters
Vol. 260, pp. 198-200 
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M. Imoto, K. Umezawa, Y. Takahashi, H. Naganawa, Y. Iitaka, H. Nakamura, Y. Koizumi, Y. Sasaki, Hamada, T. Sawa & T. Takeuchi
Isolation and structure determination of inostamycin, a novel inhibitor of phosphatidylinositol turnover 1990 Journal of National Products
Vol. 53, pp. 825-829 
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M. Imoto, N. Shimura, H. Ui & K. Umezawa
Inhibition of EGF-induced phospholipase C activation in A431 cells by erbstatin, a tyrosine kinase inhibitor 1990 Biochemical and Biophysical Research Communications
Vol. 173, pp. 208-211 
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梅沢一夫 & 井本正哉
癌遺伝子機能発現に作用する微生物二次代謝産物 1990 Cell Science(6), pp. 718-725  Google
H. Nishioka, M. Imoto, T. Sawa, M. Hamada, H. Naganawa, T. Takeuchi & K. Umezawa
Screening of phosphatidylinositol kinase inhibitors from Streptomyces. 1989 Journal of Antibiotics
Vol. 42, pp. 823-825 
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K. Umezawa, M. Imoto, T. Yamashita, T. Sawa & T. Takeuchi
Modification of cellular membrane functions by pendolmycin 1989 Japanese Journal of Cancer Research
Vol. 80, pp. 15-18 
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M. Imoto, T. Yamashita, T. Sawa, S. Kurasawa, S. Naganawa, T. Takeuchi, S. Bao-quan & K. Umezawa
Inhibition of cellular phosphatidylinositol turnover by psi-tectorigenin 1988 FEBS Letters
Vol. 230, pp. 43-46 
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T. Uchida, M. Imoto, Y. Takahashi, A. Odagawa, T. Sawa, K. Tatsuta, H. Naganawa, M. Hamada, T. Takeuchi & H. Umezawa
New potent anthracyclines, barminomycins I and II. 1988 Journal of Antibiotics
Vol. 41, pp. 404-408 
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T. Yamashita, M. Imoto, K. Isshiki, T. Sawa, H. Naganawa, S. Kurasawa, Z. Bao-quan & K. Umezawa
Isolation of a new indole alkaloid, pendolmycin from Nocardiopsis 1988 Journal of National Products
Vol. 51, pp. 1184-1187 
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K. Isshiki, M. Imoto, T. Sawa, K. Umezawa, T. Takeuchi, K. Tatsuta & H. Umezawa
Inhibition of tyrosine protein kinase by synthetic erbstatin analogs 1987 Journal of Antibiotics
Vol. 40, pp. 1209-1210 
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K. Isshiki, M. Imoto, T. Takeuchi, T. Tsuchida, T. Yoshioka, K. Tatsuta & H. Umezawa
Effective synthesis of erbstatin and its analogs 1987 Journal of Antibiotics
Vol. 40, pp. 1207-1208 
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M. Imoto, K. Umezawa, K. Isshiki, K. Kunimoto, T. Sawa, T. Takeuchi & H. Umezawa
Kinetic studies of tyrosine kinase inhibition by erbstatin 1987 Journal of Antibiotics
Vol. 40, pp. 1471-1473 
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M. Imoto, K. Umezawa, K. Komuro, T. Sawa, T. Takeuchi & H. Umezawa
Antitumor activity of erbstatin, a tyrosine protein kinase inhibitor 1987 Japanese Journal of Cancer Research
Vol. 78, pp. 329-332 
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M. Imoto, K. Umezawa, T. Sawa, T. Takeuchi & H. Umezawa
In situ inhibition of tyrosine protein kinase by erbstatin 1987 Biochemistry International
Vol. 15, pp. 989-995 
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H. Nakamura, Y. Iitaka, M. Imoto, K. Isshiki, H. Naganawa, T. Takeuchi & K. Umezawa
The structure of an epidermal growth factor-receptor kinase inhibitor, erbstatin. 1986 Journal of Antibiotics
Vol. 39, pp. 314-315 
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H. Umezawa, M. Imoto, T. Sawa, K. Isshiki, N. Matsuda, T. Uchida, H. Iinuma, M. Hamada & T. Takeuchi
Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3 1986 Journal of Antibiotics, pp. 170-173  Google Scholar
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T. Uchida, M. Imoto, T. Matsuda, H. Yoshimoto, K. Imamura, T. Sawa, H. Naganawa, T. Takeuchi & H. Umezawa
New anthracycline antibiotics: Serirubicin and 1-hydroxyserirubicin. 1985 Journal of Antibiotics
Vol. 38, pp. 795-798 
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T. Uchida, M. Imoto, Y. Watanabe, K. Miura, T. Dobashi, N. Matsuda, T. Sawa, H. Naganawa, M. Hamada, T. Takeuchi & H. Umezawa
Saquayamycins, new aquayamycin-group antibiotics. 1985 Journal of Antibiotics
Vol. 38, pp. 1171-1118 
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T. Uchida, M. Imoto, T. Matsuda, K. Imamura, Y. Hatori, T. Sawa, H. Naganawa, M. Hamada, T. Takeuchi & H. Umezawa
New antitumor antibiotics, ditrisarubicins A, B and C 1983 Journal of Antibiotics
Vol. 36, pp. 1080-1083 
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A. Hatanaka, T. Kajiwara, J. Sekiya, M. Imoto & S. Inouye
Participation and properties of lipoxygenase and hydroperoxide lyase in volatile C6-aldehyde formation from C18-unsaturated fatty acids in isolated tea chloroplasts 1982 Plant and Cell Physiology
Vol. 23, pp. 91-99 
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J. Sekiya, T. Kajiwara, M. Imoto, S. Inouye & A. Hatanaka
Effect of lipolytic acyl hydrolase on the activity for six carbon aldehyde formation in tea chloroplasts 1982 Journal of Agricultural and Food Chemistry
Vol. 30, pp. 183-185 
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